A new ICT and CHEF based visible light excitable fluorescent probe easily detects in vivo Zn2+. Issue 39 (1st April 2015)

• Record Type: Journal Article
• Authors: Aich, Krishnendu; Goswami, Shyamaprosad; Das, Sangita; Mukhopadhyay, Chitrangada Das
• Is Part Of: RSC advances. Volume 5:Issue 39(2015)
• Page Start: 31189
• Page End: 31194
• Publication Date: 2015-04-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra03353e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A new chelator and ICT donor based visible light excitable Zn 2+ sensor was designed and developed by integrating quinoline and 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde. Abstract : A new chelator and ICT donor based visible light excitable Zn 2+ sensor was designed and developed by integrating quinoline and 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde. The probe is sensitive towards Zn 2+ in absorbance as well as in fluorescence experiments in 90% aqueous medium. The sensor demonstrates Zn 2+ -specific emission enhancement due to the ICT and CHEF process with the LOD in the range of 10 −8 M. The fluorescence quantum yield of the chemosensor is only 0.02, and it increases almost 11-fold (0.22) after complexation with Zn 2+ . Interestingly, the introduction of other metal ions causes the fluorescence intensity to remain almost unchanged. Moreover, the ability of the probe (BQ) to sense Zn 2+ in living cells has been explored.