Biodegradable multi-liposomal containers. Issue 40 (2nd April 2015)

• Record Type: Journal Article
• Authors: Yaroslavov, Alexander A.; Efimova, Anna A.; Sybachin, Andrey V.; Chvalun, Sergey N.; Kulebyakina, Alevtina I.; Kozlova, Ekaterina V.
• Is Part Of: RSC advances. Volume 5:Issue 40(2015)
• Page Start: 31460
• Page End: 31464
• Publication Date: 2015-04-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra00835b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Structure of multiliposomal nanocontainer on base of anionic liposomes, polycation and polylactide. Abstract : Here we describe biodegradable multi-liposomal core–shell containers. They are made of a poly-l -lactide–polyethyleneoxyde–poly-l -lactide triblock-copolymer core covered by electrostatically adsorbed liposomes. The liposomes retain their integrity after adsorption, which allows them to be used for encapsulating bioactive compounds. The multi-liposomal containers eventually decompose, by being attacked by hydrolytic enzymes, which makes them promising for use in drug delivery.