Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles. Issue 16 (18th March 2015)

• Record Type: Journal Article
• Authors: Ding, Zhengwei; Tan, Qitao; Gao, Mingchun; Xu, Bin
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 16(2015)
• Page Start: 4642
• Page End: 4646
• Publication Date: 2015-03-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00409h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient copper-catalyzed regioselective olefinic C(sp 2 )–H bond cycloamination and acyloxylation was developed to give acyloxylated pyrazoles under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step. Abstract : A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp 2 )–H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step, using facile carboxylic acids as the acyloxylation reagents.