A Genetic Basis for Motivated Exercise. Issue 4 (October 2015)

• Record Type: Journal Article
• Authors: Good, Deborah J.; Li, Mengjiao; Deater-Deckard, Kirby
• Is Part Of: Exercise and sport sciences reviews. Volume 43:Issue 4(2015:Oct.)
• Publication Date: 2015-10
• Subjects: NSCL2/NHLH2 -- obesity -- physical activity -- SIRT -- acetylation -- dopamine -- monoamine oxidase A; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000057
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : Prior research has demonstrated a genetic basis for motivated exercise, with evidence of a role for nescient helix-loop-helix-2 (NHLH2/Nhlh2). Nhlh2 transcriptionally regulates the monoamine oxidase A (MAO-A) gene. This article examines the evidence for the hypothesis that polymorphisms in NHLH2 or MAO-A contribute to differences in the human motivation for exercise and physical activity. The genetic pathways that link exercise and motivation are discussed. Abstract : Can the genetic basis for motivated exercise be linked to a single neural pathway?