Advances in Vascular Hyporeactivity After Shock: The Mechanisms and Managements. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Duan, Chenyang; Yang, Guangming; Li, Tao; Liu, Liangming
• Is Part Of: Shock. Volume 44:Issue 6(2015:Dec.)
• Publication Date: 2015-12
• Subjects: PKC -- Rac -- Rho kinase -- shock -- therapy -- vascular hyporeactivity -- vascular reactivity; Shock -- Periodicals; Shock -- Periodicals; Choc (Pathologie) -- Périodiques; Shock; Periodicals; 616.0475
• DOI: 10.1097/SHK.0000000000000457
• Languages: English
• ISSNs: 1073-2322

Abstract

Abstract : ABSTRACT: Vascular reactivity to vasoconstrictors and vasodilators is greatly reduced after severe trauma, shock, and sepsis or multiple organ dysfunction syndrome. This reduced vascular reactivity severely interferes with the treatment of shock and other critical conditions. In particular, it interferes with the efficacy of vasoactive agents. Consequently, it is very important to elucidate the mechanisms and search for the effective treatment measures. In recent years, a lot of studies focused on the characteristics and the change rules of vascular hyporeactivity and mechanisms following shock. Also, the treatment approaches based on various mechanisms have been a hot pot these years.