An overview of normocalcemic primary hyperparathyroidism. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Pawlowska, Monika; Cusano, Natalie E.
• Is Part Of: Current opinion in endocrinology, diabetes and obesity. Volume 22:Issue 6(2015:Dec.)
• Publication Date: 2015-12
• Subjects: hyperparathyroidism -- normocalcemic -- normocalcemic primary hyperparathyroidism -- primary hyperparathyroidism; Endocrinology -- Periodicals; Diabetes -- Periodicals; Obesity -- Periodicals; Diabetes Mellitus -- Periodicals; Endocrine System Diseases -- Periodicals; Endocrine Glands -- Periodicals; Obesity -- Periodicals; Endocrinologie -- Périodiques; Diabète -- Périodiques; Obésité -- Périodiques; Diabetes; Endocrinology; Obesity; Periodicals; 616.4
• DOI: 10.1097/MED.0000000000000198
• Languages: English
• ISSNs: 1752-296X

Abstract

Abstract : Purpose of review: Normocalcemic primary hyperparathyroidism (PHPT) received special attention in the publication of the conference proceedings from the Fourth International Workshop on the Management of Asymptomatic PHPT, although much remains unknown about the disorder. Recent findings: Observational studies have found that despite maintaining normocalcemia, patients with normocalcemic PHPT have a high incidence of kidney stones and osteoporosis. Small studies focusing on the cardiovascular implications of normocalcemic PHPT have shown a possible association with hypertension and an atherogenic lipid profile, but not insulin resistance. Recent data from small cohorts show that subjects with normocalcemic PHPT respond to medical therapy and have a positive densitometric response following parathyroid surgery. Summary: The available evidence suggests that patients with normocalcemic PHPT develop complications of PHPT, despite having normal calcium levels. Most data come from referral populations and information regarding a mild, asymptomatic form of the disease is lacking. Future research requires a standardized approach to the diagnostic criteria of normocalcemic PHPT.