AMBULATORY BLOOD PRESSURE PATTERNS IN PATIENTS WITH RETINAL VEIN OCCLUSION. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Rao, Vishal N.; Ulrich, J. Niklas; Viera, Anthony J.; Parlin, Anna; Fekrat, Sharon; Chavala, Sai H.
• Is Part Of: Retina. Volume 36:Issue 12(2016:Dec.)
• Page Start: 2304
• Page End: 2310
• Publication Date: 2016-12
• Subjects: retinal vein occlusion -- ambulatory blood pressure monitoring -- nondipper -- cardiovascular disease risk -- epidemiology -- diagnostic tests; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000001071
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Ambulatory blood pressure monitoring reveals nocturnal hypertension and abnormal nocturnal dipping pattern in retinal vein occlusion patients, which are known to be associated with end-organ damage and poor health outcomes. Abstract : Purpose: Failure of blood pressure (BP) to dip during sleep (nondipper pattern) is associated with cardiovascular disease and stroke. The prevalence and degree of nondipping and masked hypertension in patients with retinal vein occlusion (RVO), which is associated with stroke, has not been previously examined. Methods: We measured clinic and 24-hour ambulatory BPs in 22 patients with RVO and 20 control participants without known eye disease matched by age and sex. Mean BP dipping, defined as the ratio of difference in mean awake and sleep systolic BPs to mean awake systolic BP, and masked and nocturnal hypertension were compared between groups. Results: Mean 24-hour ambulatory BP was 144/79 mmHg among those with RVO and 136/77 mmHg among controls. Patients with RVO had an almost 2-fold higher prevalence of nondipping pattern (80.8% [95% confidence interval, 52.8–94.1] vs. 50.4% [95% confidence interval, 26.1–74.5]; P = 0.008). Average sleep systolic BP dip in patients with RVO was 6.1% versus 11.9% in controls ( P = 0.004). More patients with RVO had masked hypertension by ambulatory BPs than controls (71% vs. 50%), but this difference was not statistically significant. Conclusion: Our data suggest an association between RVO and nondipper BP pattern. Ambulatory BP monitoring may be useful in the evaluation of patients with RVO by identifying those who may benefit from more aggressive BP control.