A series of new supramolecular polycations for effective gene transfection. Issue 13 (11th February 2015)

• Record Type: Journal Article
• Authors: Hu, Hao; Song, Hai-Qing; Yu, Bing-Ran; Cai, Qing; Zhu, Yun; Xu, Fu-Jian
• Is Part Of: Polymer chemistry. Volume 6:Issue 13(2015)
• Page Start: 2466
• Page End: 2477
• Publication Date: 2015-02-11
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c4py01756k
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : A series of efficient supramolecular assemblies were prepared for gene delivery by assembling different α-CD derivatives with multiple β-CD-cored polycations. Abstract : The development of safe and effective supramolecular polycations has attracted much attention. In this work, a series of novel cyclodextrin (CD)-based supramolecular assemblies were readily prepared via the host–guest interaction by assembling different adamantane-functionalized α-CD derivatives with multiple β-CD-cored polycations. The supramolecular assemblies were investigated in terms of their pDNA-binding capabilities, cytotoxicities, cellular internalization and gene transfection efficiencies in HEK293, HepG2 and C6 cell lines. The supramolecular polycations displayed low cytotoxicities, similar to those of the CD-cored carriers. After self-assemblies, the gene transfection efficiencies and antitumor abilities of the supramolecular carriers were significantly enhanced. The present study demonstrates that such supramolecular preparation of CD-based polycations could provide a flexible strategy for the design and development of new assemblies with high efficiency and low cytotoxicity.