Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population. Issue 6 (October 2015)

• Record Type: Journal Article
• Authors: Huang, Qin; Shi, Jiong; Sun, Qi; Gold, Jason S.; Chen, Jieyu; Wu, Hongyan; Yu, Huiping; Zhang, Yifen; Mashimo, Hiroshi; Yu, Chenggong; Manasco, Travis; Guan, Wenyan; Lauwers, Gregory Y.
• Is Part Of: Pathology. Volume 47:Issue 6(2015:Oct.)
• Publication Date: 2015-10
• Subjects: Cardia -- Chinese -- gastric cancer -- Helicobacter pylori; Pathology -- Periodicals; 616.0705
• DOI: 10.1097/PAT.0000000000000276
• Languages: English
• ISSNs: 0031-3025

Abstract

Abstract : Summary: Clinicopathological characteristics of small gastric carcinoma have not been well defined in Chinese patients. The aim of this study was to investigate and compare small proximal (PGC, n = 111) with distal (DGC, n = 202) gastric carcinoma in 313 consecutive surgically resected small (⩽2 cm) gastric carcinomas diagnosed with the WHO criteria. PGC patients were significantly older (average age 63 years versus 59 in DGCs) with a male/female ratio of 3:1. Most tumours were clustered along the lesser curvature (74% in PGCs and 65% in DGCs). Compared to DGCs, PGCs showed a protruded gross pattern significantly more frequently and were significantly better differentiated with a significantly wider histomorphological spectrum. Surprisingly, PGCs were composed of significantly fewer signet-ring cell carcinomas (1% versus 16% in DGCs) but were significantly more deeply invasive, compared to DGCs. Lymph node metastasis was detected in 23% overall, but was significantly less frequent in PGCs (16%) than in DGCs (26%) ( p < 0.05). However, the difference in survival between the two groups was not statistically significant. Our results demonstrate that in Chinese patients, PGCs display distinct clinicopathological characteristics, compared to DGCs.