Comparison of efavirenz and protease inhibitor-based combination antiretroviral therapy regimens in treatment-naïve people living with HIV with baseline resistance. (17th July 2016)

• Record Type: Journal Article
• Authors: Lim, Charlotte; McFaul, Katie; Kabagambe, Samuel; Sonecha, Sonali; Jones, Rachael; Asboe, David; Pozniak, Anton; Nwokolo, Nneka; Boffito, Marta
• Is Part Of: AIDS. Volume 30:Number 11(2016)
• Publication Date: 2016-07-17
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000001140
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : A retrospective cohort analysis comparing the efficacy of boosted protease inhibitor-based and efavirenz-based combination antiretroviral therapy in treatment-naïve people living with HIV with baseline resistance found that efavirenz-based treatment led to a shorter mean time to undetectable viral load. A higher proportion of patients with nonnucleoside reverse transcriptase inhibitor related baseline resistance mutations in the efavirenz-treatment group achieved an undetectable viral load at both 6 and 12 months post-treatment initiation, compared with the boosted protease-inhibitor-treatment group. Supplementary content:http://links.lww.com/QAD/A930 . Abstract : Supplemental Digital Content is available in the text