Predictors of Outcome in Pediatric Osteomyelitis: Five Years Experience in a Single Tertiary Center. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Martin, Andrew C.; Anderson, Denise; Lucey, Julie; Guttinger, Robin; Jacoby, Peter A.; Mok, Tabitha J.; Whitmore, Timothy J.; Whitewood, Colin N.; Burgner, David P.; Blyth, Christopher C.
• Is Part Of: Pediatric infectious disease journal. Volume 35:Issue 4(2016)
• Publication Date: 2016-04
• Subjects: osteomyelitis -- children -- outcome; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001031
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Background: Acute haematogenous osteomyelitis is a bacterial infection of bone, which occurs most frequently in children. Outcomes are excellent for the majority of children, but a minority develop complicated osteomyelitis. Predicting which children will develop complicated osteomyelitis remains a challenge, particularly in developed countries where most patients are discharged home after a relatively short period in hospital. Methods: We conducted a 5-year retrospective case note review of all children aged 3 months to 16 years admitted with a diagnosis of acute haematogenous osteomyelitis. We compared standardized clinical and laboratory parameters in those who developed simple and complicated osteomyelitis. Results: Of the 299 children who met inclusion, 241 (80.6%) had simple and 58 (19.4%) had complicated osteomyelitis. The major predictors of complicated disease were older age, a temperature greater than 38.5°C and a higher C-reactive protein at admission. Conclusions: A risk prediction model, utilizing information available shortly after hospitalization, allows early identification of children at greatest risk of developing complicated osteomyelitis. Abstract : Supplemental Digital Content is available in the text.