Accessible protocol for asymmetric hydroformylation of vinylarenes using formaldehyde. Issue 16 (18th March 2015)

• Record Type: Journal Article
• Authors: Morimoto, Tsumoru; Fujii, Tetsuji; Miyoshi, Kota; Makado, Gouki; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Kakiuchi, Kiyomi
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 16(2015)
• Page Start: 4632
• Page End: 4636
• Publication Date: 2015-03-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00378d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The rhodium(i )/chiral Ph-bpe-catalyzed reaction of vinylarenes with formaldehyde provides an accessible protocol for asymmetric hydroformylation to enantioenriched aldehydes in high yields. Abstract : We report herein on an accessible protocol for the asymmetric hydroformylation of vinylarenes using formaldehyde as a substitute for syngas. The regioselectivity (branched/linear = up to 96/4) and enantioselectivity (up to 95% ee) can be attributed to the use of chiral Ph-bpe as a ligand.