Renal Cell Carcinoma Metastatic to a Pituitary FSH/LH Adenoma: Case Report and Review of the Literature. (31st July 2014)

• Record Type: Journal Article
• Authors: Magnoli, Francesca; Finzi, Giovanna; Riva, Cristina; Capella, Carlo
• Is Part Of: Ultrastructural pathology. Volume 38:Number 6(2014:Dec.)
• Page Start: 430
• Page End: 437
• Publication Date: 2014-07-31
• Subjects: Clear cell renal cell carcinoma -- electron microscopy -- metastasis -- pituitary adenoma; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.3109/01913123.2014.937843
• Languages: English
• ISSNs: 0191-3123

Abstract

Abstract: Metastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastatic to a FSH/LH/α-subunit pituitary adenoma and systematically review the literature. Immunohistochemistry and electron microscopy were performed to characterize both neoplastic components at the morphological level. Moreover, it was hypothesized that expression of VEGF and of the corresponding receptor VEGFR1 could be implicated in the development of the carcinomatous metastasis within the adenoma.