Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors. Issue 4 (May 2016)

• Record Type: Journal Article
• Authors: Kotsopoulos, Ioannis C.; Kucukmetin, Ali; Mukhopadhyay, Asima; Lunec, John; Curtin, Nicola J.
• Is Part Of: International journal of gynecological cancer. Volume 26:Issue 4(2016)
• Publication Date: 2016-05
• Subjects: Poly(ADP-ribose) polymerase -- PARP -- Cervical cancer -- CIN -- Carcinogenesis; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000654
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Abstract: Treatment options for disease recurrence of women treated for locally advanced and advanced cervical cancer are very limited—largely palliative chemotherapy. The low efficacy of the currently available drugs raises the need for new targeted agents. Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) have emerged as a promising class of chemotherapeutic agents in cancers associated with defects in DNA repair. Their therapeutic potential in cervical cancer is currently being evaluated in 3 ongoing clinical trials. Here we review the available information regarding all the aspects of PARP in cervical intraepithelial neoplasia and invasive cervical cancer, from expression and the mechanism of action to the role of the polymorphisms in the pathogenesis of the disease, as well as the potential of the inhibitors. We finally propose a new unifying theory regarding the role of PARPs in the development of cervical carcinomas.