Doppler velocimetry of the ovarian artery as a tool to detect LH surge in stimulated cycles. (1st July 2014)

• Record Type: Journal Article
• Authors: Giugliano, Emilio; Cagnazzo, Elisa; Vesce, Fortunato; Giugliano, Brunella; Caserta, Donatella; Moscarini, Massimo; Caldarelli, Carola; Stellin, Giancarlo; Marci, Roberto
• Is Part Of: Gynecological endocrinology. Volume 30:Number 9(2014:Sep.)
• Page Start: 627
• Page End: 631
• Publication Date: 2014-07-01
• Subjects: Artificial insemination -- doppler color ultrasonography -- female infertility -- luteinizing hormone -- ovulation; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2014.911276
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Our aim was to assess the velocimetric pattern of the ovarian artery as a possible marker of LH surge in stimulated cycles. A total of 130 women undergoing ovarian stimulation for intrauterine insemination were randomized in two groups. Each woman was stimulated with 75 IU of recombinant FSH starting from the third day of the cycle. Velocimetric indices of the dominant ovarian artery were compared between patients with spontaneous LH surge and those needing HCG administration to trigger dominant follicle rupture. The pulsatility index and the ratio between peak systolic flow and lowest diastolic flow were significantly higher in women that had a spontaneous triggering of ovulation. These parameters had a high and very significant positive correlation with the dosage of luteinizing hormone. Threshold values of 2.60 for PI and 7.68 for S/D had a high sensitivity and specificity to predict LH surge. These velocimetric results demonstrated that an increased resistance in the dominant ovarian artery is correlated to LH surge in stimulated cycles. It may represent a sign of relevant clinical utility in timing of intrauterine insemination and/or natural intercourse. Chinese abstract: 我们的目的是评价在促排卵周期中卵巢动脉的血流速度形式可能作为一个LH峰的标志物。将130名正在进行促排卵拟行宫腔内人工授精的女性随机分为两组。比较有自发LH峰患者和需要给予HCG以诱发优势卵泡破裂患者的主要卵巢动脉的血流指数。有自发排卵的女性，其脉动指数和收缩期峰值流量与最低舒张流量之比明显较高。这些参数与黄体生成素的水平有较高和极其显著的正相关。这些参数的阈值（PI为2.60，S/D为7.68）对于预测LH峰有较高的敏感性和特异性。这些测速结果说明，主要卵巢动脉的阻力增加与促排卵周期中的LH峰相关联。它可作为一项临床相关的指标，应用于指导选择宫腔内人工授精和/或夫妻同房的时机。