Geographical and social influences on genetic diversity within the Egyptian population: analyses of Alu insertion polymorphisms. (12th September 2013)

• Record Type: Journal Article
• Authors: Salem, Abdel Halim; Bahri, Raoudha; Jarjanazi, Hamdi; Chaabani, Hassen
• Is Part Of: Annals of human biology. Volume 41:Number 1(2014:Jan./Feb.)
• Page Start: 61
• Page End: 66
• Publication Date: 2013-09-12
• Subjects: Alu insertions -- Egyptian population -- genetic diversity -- geographical and social influences; Human biology -- Periodicals; 612
• DOI: 10.3109/03014460.2013.826734
• Languages: English
• ISSNs: 0301-4460

Abstract

Abstract: Background : The geographical location of Egypt at the crossroads of several major cultural areas between North Africa and the Middle East has contributed to its population history. Aim : To analyse the genetic structure of the population living in two geographical parts of Egypt. Subjects and methods : A sample of 112 Egyptians from the North African part of Egypt (Ismailia sample) and a sample of 52 Egyptians from the Asian part Sinai, have been analysed using 10 Alu insertion polymorphisms. Results : The results of the present study showed a significant genetic difference between the Sinai and Ismailia samples. The latter showed an evident genetic affinity with North African populations; whereas the Sinai sample was found to be genetically closer to the Middle East populations. The Sinai sample showed a low average heterozygosity, unlike that found in the Ismailia sample. Conclusion : This study provides new insights into the genetic structure of the Egyptian population living in a land bridge between Africa and Asia. Results suggest a genetic discontinuity between the Sinai population and that of the North African part of Egypt. This discontinuity would have been maintained thanks to geo-climatic and social factors.