Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan. Issue 26 (27th February 2015)

• Record Type: Journal Article
• Authors: Ramasamy, T.; Ruttala, H. B.; Choi, J. Y.; Tran, T. H.; Kim, J. H.; Ku, S. K.; Choi, H. G.; Yong, C. S.; Kim, J. O.
• Is Part Of: Chemical communications. Volume 51:Issue 26(2015)
• Page Start: 5758
• Page End: 5761
• Publication Date: 2015-02-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc00482a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer. Abstract : We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer. It shows great potential for the treatment of a broad range of cancers.