Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery. Issue 32 (23rd March 2015) - Subramanian, Nithya
Abstract : A chimeric aptamer–DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted delivery of DNAzyme to cancer cells. Abstract : A chimeric aptamer–DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.