A new biomimetic route to engineer enzymatically active mechano-responsive materials. Issue 26 (26th February 2015)

• Record Type: Journal Article
• Authors: Rios, César; Longo, Johan; Zahouani, Sarah; Garnier, Tony; Vogt, Cédric; Reisch, Andreas; Senger, Bernard; Boulmedais, Fouzia; Hemmerlé, Joseph; Benmlih, Karim; Frisch, Benoît; Schaaf, Pierre; Jierry, Loïc; Lavalle, Philippe
• Is Part Of: Chemical communications. Volume 51:Issue 26(2015)
• Page Start: 5622
• Page End: 5625
• Publication Date: 2015-02-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc00329f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Uniaxial stretching of β-galactosidase anchored to a cross-linked polyelectrolyte multilayer leads to the tuning of the material catalytic activity. Abstract : Using modified β-galactosidase covalently linked to cross-linked polyelectrolyte multilayers (PEM), catalytically active materials have been designed. Their enzymatic activity can be modulated, partially in a reversible way, simply by stretching. This strategy, based on enzyme conformational changes, constitutes a new tool for the development of biocatalytic mechano-responsive materials.