Design and synthesis of fluorenone-based dyes: two-photon excited fluorescent probes for imaging of lysosomes and mitochondria in living cells. Issue 16 (19th March 2015)

• Record Type: Journal Article
• Authors: Capodilupo, A. L.; Vergaro, V.; Fabiano, E.; De Giorgi, Milena; Baldassarre, F.; Cardone, Antonio; Maggiore, A.; Maiorano, V.; Sanvitto, D.; Gigli, G.; Ciccarella, G.
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 16(2015)
• Page Start: 3315
• Page End: 3323
• Publication Date: 2015-03-19
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c4tb02116a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Three fluorenone-based two-photon fluorescent probes for specific targeting of lysosomes and mitochondria in cancer cells. Abstract : Three fluorenone-derived two-photon fluorescent probes (TK ) targeting the lysosomes (TK-Lyso ) and mitochondria (TK-Mito1 andTK-Mito2 ) were synthesized by introducing different diphenylamine moieties into the fluorenone core. TheTK dyes showed high biocompatibility and long-term retention, low cytotoxicity, large Stokes shift and good fluorescence quantum yield. The results of the present work disclose a class of organic dyes with potential wide applications as specific and efficient probes for lysosomes and mitochondria in the study of various biological processes.