Circulating Monoclonal Light Chains and Acute Kidney Injury: The Role of the Renal Biopsy with Emphasis on Ultrastructural Evaluation in Assessing and Understanding Renal Injury. (9th April 2015)

• Record Type: Journal Article
• Authors: Aufman, Jeffrey; Herrera, Guillermo A.
• Is Part Of: Ultrastructural pathology. Volume 39:Number 3(2015:Jun.)
• Page Start: 159
• Page End: 168
• Publication Date: 2015-04-09
• Subjects: Light chains -- tubulopathy -- ultrastructure; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.3109/01913123.2015.1013653
• Languages: English
• ISSNs: 0191-3123

Abstract

Abstract: Tubular interstitial injury as a consequence of circulating monotypical light chains in patients with an underlying plasma cell dyscrasia may be difficult to identify. Renal involvement is a common early manifestation in these patients, and accurate/careful pathologic evaluation can uncover an underlying plasma cell dyscrasia. While immunofluorescence evaluation can detect monotypical deposition of light chains in the tubular interstitial compartment and may suggest a possible underlying plasma cell dyscrasia, electron microscopic examination is crucial in documenting such involvement. Ultrastructural immunolabeling can help in solidifying the pathological assessment.