Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor AIP induced antinociception in rats with mononeuropathy. (10th July 2015)

• Record Type: Journal Article
• Authors: Bian, Hui; Yu, Long-Chuan
• Is Part Of: Neuroscience letters. Volume 599(2015)
• Page Start: 129
• Page End: 132
• Publication Date: 2015-07-10
• Subjects: Antinociceptive effect -- Calcium/calmodulin-dependent protein kinase II (CaMKII) -- Hindpaw withdrawal latency -- Mononeuropathy -- Myristoylated autocamtide-2-inhibitory peptide (AIP) -- Nucleus accumbens; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2015.05.048
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Intra-NAc injection of AIP induced antinociception in rats with mononeuropathy. CaMKII is involved in pain modulation in NAc of rats with mononeuropathy. There are no significant differences in morphine- and AIP-induced antinociception. Abstract: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine- dependent protein kinase, which has been implicated in pain modulation at different levels of the central nervous system. The present study was performed in rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 3 μg, 6 μg and 12 μg of myristoylated autocamtide-2-inhibitory peptide (AIP), the CaMKII inhibitor, dose-dependently increased the HWL to noxious thermal and mechanical stimulation in rats with mononeuropathy. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and AIP group. Taken together, the results showed that intra-NAc injection of AIP induced significant antinociceptive effects in rats with mononeuropathy, indicating that CaMKII may play an important role in the transmission and/or modulation of nociceptive information in the NAc in rats with mononeuropathy.