Characterization of a novel canine T-cell line established from a dog with cutaneous T-cell lymphoma. Issue 2 (November 2017)

• Record Type: Journal Article
• Authors: Hara, Kyohei; Iio, Aki; Asahina, Ryota; Takahashi, Maiko; Mori, Takashi; Nishida, Hidetaka; Kamishina, Hiroaki; Sakai, Hiroki; Kitoh, Katsuya; Mizuno, Takuya; Tsujimoto, Hajime; Maeda, Sadatoshi
• Is Part Of: Journal of dermatological science. Volume 88:Issue 2(2017:Nov.)
• Page Start: 254
• Page End: 256
• Publication Date: 2017-11
• Subjects: Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2017.06.001
• Languages: English
• ISSNs: 0923-1811

Abstract

Highlights: Canine cutaneous T-cell lymphoma (CTCL) has the potential to be used as a model animal for human primary cutaneous aggressive epidermotropic CD8 + cytotoxic T-cell lymphoma (CD8 + PCECTL). A novel canine CTCL cell line, termed EO-1, was established from a dog with CTCL. EO-1 expressed CD3 and CD8 with a high expression of a functional CC chemokine receptor 4 that was biologically active to both human and mouse CCL17/TARC. EO-1 may be a useful tool in the research for not only canine CTCL but also human CD8 + PCECTL.