Assessment of osteoinduction using a porous hydroxyapatite coating prepared by micro-arc oxidation on a new titanium alloy. (December 2015)

• Record Type: Journal Article
• Authors: Jing, Wensen; Zhang, Minghua; Jin, Lei; Zhao, Jian; Gao, Qing; Ren, Min; Fan, Qingyu
• Is Part Of: International journal of surgery. Volume 24:Part A(2015)
• Page Start: 51
• Page End: 56
• Publication Date: 2015-12
• Subjects: Hydroxyapatite -- Micro-arc oxidation -- Coating -- Titanium alloy; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; 617.005
• DOI: 10.1016/j.ijsu.2015.08.030
• Languages: English
• ISSNs: 1743-9191

Abstract

Abstract: Surface modification and material improvement is now an important way to improve the osseointegration between bone and uncemented prothesis. The purpose of this study was to investigate the bone ingrowth potential of porous hydroxyapatite (HA) coatings prepared by micro-arc oxidation (MAO) on Ti–3Zr–2Sn–3Mo–25Nb, a new titanium alloy. HA-coated specimens were implanted in the left proximal femoral medullary canal of beagles for 4, 12, and 24 weeks, and uncoated specimens were implanted in the right as a control. The surface morphology and phase composition were investigated with environmental scanning electron microscopy and X-ray diffractometry. The bone ingrowth was assessed by histomorphometry. A pull-out test was performed to assess the mechanical performance of the bone–implant interface. A porous coating was well prepared on the new titanium alloy by using the MAO method. The bone-to-implant contact was significantly higher for the HA-coated group compared to that in the uncoated group. Mechanical tests showed that the HA-coated group had significantly higher maximum force at the bone–implant interface compared to the uncoated specimens. MAO is a suitable coating approach for this new titanium alloy. The HA coating prepared by this approach can significantly promote bone ingrowth and the mechanical performance of the bone–implant interface. Highlights: MAO technology developed a uniform coating on porous implant surfaces. An improvement in osteogenic induction was showed at the bone–implant interface. HA-coated specimen has a porous structure for new bone ingrowth. We examine an increased degradation time in vivo.