Antiulcer properties of fruits and vegetables: A mechanism based perspective. (October 2017)

• Record Type: Journal Article
• Authors: Harsha, Choudhary; Banik, Kishore; Bordoloi, Devivasha; Kunnumakkara, Ajaikumar B.
• Is Part Of: Food and chemical toxicology. Volume 108(2017)Part A
• Page Start: 104
• Page End: 119
• Publication Date: 2017-10
• Subjects: Gastric ulcer -- Fruits -- Vegetables -- Antioxidant -- Inflammation; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2017.07.023
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Gastric ulcer is the damage caused to mucosal layer of the stomach under the action of various factors like high levels of acid and pepsin, invasion by Helicobacter pylori, etc. Although most cases have been controlled and the rate of ulcer occurrence has reduced over the last few decades, gastric ulcer still holds a prime concern today. A range of palliative medicines comprising proton pump inhibitors, H2 receptor antagonists, COX-2 inhibitors (coxibs) is widely in use and patients have also been administered with acid suppression therapies. But these remedies aggravate the condition of patients causing severe side effects, or rather impart temporary relief. Therefore, it is highly imperative to develop safe and effective therapies for the treatment of gastric ulcer. Nature provides us various fruits and vegetables that can combat gastric ulcer through multiple mechanisms; predominantly via antioxidant, anti-inflammatory, antisecretory, antimicrobial, anticholinergic and cytoprotective activity, inhibition of small intestinal propulsion etc. Various phytochemicals from fruits and vegetables such as phenolics, flavonoids, tannins and saponins play a vital role in the prevention and cure of gastric ulcer. This review is a compendium of all fruits and vegetables known for their profound antiulcer effect and their underlying mechanisms of action. Highlights: Gastric ulcer poses a major threat to mankind. Peptic ulcer claimed the lives of 301, 400 people around the world in 2013. Fruits and vegetables are safe, inexpensive and have profound antiulcer effect. They are antioxidant, antiinflammatory, cytoprotective and inhibit acid secretion. Phytochemicals present in them exert their antiulcer potential.