Calcium, Barium and Strontium apatites: A new generation of catalysts in the Biginelli reaction. Issue 46 (16th November 2017)

• Record Type: Journal Article
• Authors: Ben Moussa, Sana; Lachheb, Jalel; Gruselle, Michel; Maaten, Birgit; Kriis, Kadri; Kanger, Tõnis; Tõnsuaadu, Kaia; Badraoui, Béchir
• Is Part Of: Tetrahedron. Volume 73:Issue 46(2017)
• Page Start: 6542
• Page End: 6548
• Publication Date: 2017-11-16
• Subjects: Biginelli reaction -- Hydroxyapatite -- Modified hydroxyapatite -- Catalysis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.09.051
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: We describe herein the use of Calcium, Barium and Strontium hydroxyapatites (CaHAp, BaHAp and SrHAp) as well as CaHAp containing Magnesium, Copper, Zinc and Palladium (MgHAp, CuHAp, ZnHAp and PdHAp) as catalysts in the Biginelli reaction. The efficiency of CaHAp and SrHAp is very low, leading to the expected 3, 4-dihydropyrimidin-2(1H)-one in poor yields. Mixed Ba5 Sr5 HAp and Ba10 HAp show interesting catalytic properties, especially Ba10 HAp leading to pure isolated reaction products in good yields. The use of modified CaHAp seems to be of interest in regard to the yield obtained. Nevertheless the release of Mg, Cu, Zn and Pd ions in the solution during the catalytic process makes the use of such modified apatites less effective. Graphical abstract: Catalyst = CaHAp, BaHAp, SrHAp Zn(II)-, Pd(II)-HAp, Cu(II)-HAp, Mg(II)HAp.