Aflatoxin B1-induced epigenetic alterations: An overview. (November 2017)

• Record Type: Journal Article
• Authors: Dai, Yaqi; Huang, Kunlun; Zhang, Boyang; Zhu, Liye; Xu, Wentao
• Is Part Of: Food and chemical toxicology. Volume 109:Part 1(2017)
• Page Start: 683
• Page End: 689
• Publication Date: 2017-11
• Subjects: Aflatoxin B1 -- Epigenetics -- DNA methylation -- Histone modifications -- Non-coding RNA; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2017.06.034
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has been well investigated, and it may result in severe health problems including carcinogenesis, mutagenesis, growth retardation, and immune suppression. Epigenetic modifications including DNA methylation, histone modifications and regulation of non-coding RNA play an important role in AFB1-induced disease and carcinogenesis. To better understand the evidence for AFB1-induced epigenetic alterations and the potential mechanisms of the toxicity of AFB1, we conducted a review of published studies of AFB1-induced epigenetic alterations. Highlights: Epigenetic mechanisms investigation has begun to draw more attention and become an evolving trend in the field of toxicology. Regulation of DNA methylation, histone modifications and non-coding RNAs in AFB1 toxic mechanisms are overviewed. The epigenetic regulating network of AFB1 induced toxicity is proposed.