The effects of striatal silent lacunar infarction on the substantia nigra and movement disorders in Parkinson's disease: A follow-up study. (October 2017)

• Record Type: Journal Article
• Authors: Zhang, Guohua; Zhang, Chengguo; Zhang, Yuhu; Wang, Yukai; Nie, Kun; Zhang, Bin; Xie, Haiqun; Lu, Jiancong; Wang, Lijuan
• Is Part Of: Parkinsonism & related disorders. Volume 43(2017)
• Page Start: 33
• Page End: 37
• Publication Date: 2017-10
• Subjects: Striatal silent lacunar infarction -- Parkinson disease -- Substantia nigra -- Diffusion kurtosis imaging -- Movement disorder; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.06.020
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Objective: Striatal silent lacunar infarction (SSLI) is associated with structural changes to the substantia nigra (SN), detectable by diffusion kurtosis imaging (DKI). In this follow-up study, we investigated the effects of SSLI on the SN and movement disorders in patients with Parkinson's disease (PD). Methods: A total of 60 untreated patients with early-stage PD, divided into control and SSLI groups, were enrolled in this study. All participants underwent conventional MRI and DKI twice; at baseline and after a 1-year period. We analyzed the differences of the following variables between the two groups: mean kurtosis (MK) values of the SN, the severity of disease, daily dosage of levodopa, and the variation of these indexes from baseline to 1-year visit. Logistic regression analysis was used to identify the major risk factors for SSLI in PD patients. Results: 1. All variables showed significant differences between the two groups. 2. The variation in MK values of the SN had a positive correlation with the variation in the severity of disease. 3. Hypertension and hyperhomocysteinemia were independent factors for SSLI in patients with PD. Conclusion: As PD progresses, movement disorders become more prominent, with increased structural changes to the SN, especially in patients with SSLI. Furthermore, PD patients with hypertension and hyperhomocysteinemia are more likely to have SSLI. Highlights: Movement disorders in PD patients aggravate with structural changes in the SN. It is more prominent in PD patients with striatal silent lacunar infarction (SSLI). Hypertension and hyperhomocysteinemia are major factors for SSLI in patients with PD.