Cervical dystonia patients display subclinical gait changes. (October 2017)

• Record Type: Journal Article
• Authors: Esposito, Marcello; Dubbioso, Raffaele; Peluso, Silvio; Picone, Antonio; Corrado, Bruno; Servodio Iammarone, Clemente; Allocca, Roberto; Manganelli, Fiore; Santoro, Lucio; Fasano, Alfonso
• Is Part Of: Parkinsonism & related disorders. Volume 43(2017)
• Page Start: 97
• Page End: 100
• Publication Date: 2017-10
• Subjects: Gait -- Cervical dystonia -- Botulinum toxin; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.07.005
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Introduction: Gait disorders in cervical dystonia (CD) are reported in patients under DBS or in severe cases complicated with spinal deformities. Objective: to assess walking motor pattern in CD patients without DBS and not presenting scoliosis. Methods: Computerized gait analysis (CGA) was performed in CD patients, before and after botulinum toxin (BoNT) injections, and in healthy controls (HC). Spatiotemporal (ST) parameters were compared between CD and HC groups. Correlation analysis was conducted between ST parameters and clinical features of CD patients. Results: CD patients demonstrated a significant reduction of velocity, stride length, % of swing phase, and dynamic stability index while stride and swing time were increased. No significant effect of BoNT was detected. A significant inverse correlation was found between TWSTRS and stride length. Conclusion: CD patients may have a slow gait with subclinical evidence. Our data suggest this alteration might be an endophenotipic feature of CD. Highlights: Computerized gait analysis was performed in 13 cervical dystonia patients. DBS patients or with spine deformities were excluded. Spatio-temporal parameters were consistent with hypokinetic gait. Walking parameters did not change after botulinum toxin treatment. Subclinical gait impairment may be an intrinsic feature of cervical dystonia.