Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis. Issue 19 (1st October 2015)

• Record Type: Journal Article
• Authors: Cheng, Yuan-Bin; Tsai, Yi-Hong; Lo, I-Wen; Haung, Chen-Chang; Tsai, Yu-Chi; Beerhues, Ludger; El-Shazly, Mohamed; Hou, Ming-Feng; Yuan, Shyng-Shiou; Wu, Chin-Chung; Chang, Fang-Rong; Wu, Yang-Chang
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 19(2015)
• Page Start: 4333
• Page End: 4336
• Publication Date: 2015-10-01
• Subjects: Pandanus utilis -- Alkaloid -- Indolizidine -- Biosynthetic pathway; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.07.041
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two novel alkaloids named pandalisines A (1 ) and B (2 ), constituting a new class of C8-substituted indolizidine moiety, were isolated from the leaves of Pandanus utilis . The structures of these new compounds were established by their mass and spectroscopic data. The absolute configuration was determined by the comparison of experimental CD and calculated ECD spectra. A plausible biosynthetic pathway for compounds1 and2 is advanced. The cytotoxic activities of the isolated alkaloids against A-549, Hep-G2, and MDA-MB-231 cancer cell lines were evaluated. The result showed that1 and2 are the first non-cytotoxic indolizidine alkaloids.