Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2). Issue 19 (1st October 2015)

• Record Type: Journal Article
• Authors: Liu, Qingjie; Batt, Douglas G.; Lippy, Jonathan S.; Surti, Neha; Tebben, Andrew J.; Muckelbauer, Jodi K.; Chen, Lin; An, Yongmi; Chang, Chiehying; Pokross, Matt; Yang, Zheng; Wang, Haiqing; Burke, James R.; Carter, Percy H.; Tino, Joseph A.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 19(2015)
• Page Start: 4265
• Page End: 4269
• Publication Date: 2015-10-01
• Subjects: Bruton's tyrosine kinase (BTK) -- Janus kinase 2 (JAK2) -- Carbazole; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.07.102
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Four series of disubstituted carbazole-1-carboxamides were designed and synthesised as inhibitors of Bruton's tyrosine kinase (BTK). 4, 7- and 4, 6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors of BTK, while 3, 7- and 3, 6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors of Janus kinase 2 (JAK2).