Anaplastic pleomorphic xanthoastrocytoma with spinal leptomeningeal spread at the time of diagnosis in an adult. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Benjamin, Carolina; Faustin, Arline; Snuderl, Matija; Pacione, Donato
• Is Part Of: Journal of clinical neuroscience. Volume 22:Issue 8(2015:Aug.)
• Page Start: 1370
• Page End: 1373
• Publication Date: 2015-08
• Subjects: Anaplastic -- Craniospinal dissemination -- Glioma -- Leptomeningeal spread -- Pleomorphic xanthoastrocytoma; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2015.02.026
• Languages: English
• ISSNs: 0967-5868

Abstract

Abstract: We describe the first patient, to our knowledge, with anaplastic pleomorphic xanthoastrocytoma (PXA) with spinal leptomeningeal spread at the time of diagnosis and present a review of the literature. PXA is a tumor that typically has an indolent course but occasionally, when anaplastic features are present, behaves in a more aggressive manner. We found that PXA with spinal leptomeningeal spread at the time of diagnosis confers a worse prognosis. Craniospinal imaging should be obtained at time of diagnosis of PXA and the presence of leptomeningeal spread may be indicative of a more aggressive disease process.