PH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment. Issue 30 (18th March 2015)

• Record Type: Journal Article
• Authors: Negrini, Renata; Fong, Wye-Khay; Boyd, Ben J.; Mezzenga, Raffaele
• Is Part Of: Chemical communications. Volume 51:Issue 30(2015)
• Page Start: 6671
• Page End: 6674
• Publication Date: 2015-03-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c4cc10274f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. Abstract : A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment.