Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification. Issue 16 (15th August 2015)

• Record Type: Journal Article
• Authors: El-Gendy, Bahaa El-Dien M.; Rateb, Mostafa E.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 16(2015)
• Page Start: 3125
• Page End: 3128
• Publication Date: 2015-08-15
• Subjects: Diketopiperazine -- Marine fungus -- Antibacterial -- BOC group -- DNA amplification; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.06.010
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Nine diketopiperazines were characterized from the culture of marine fungal isolate MR2012 which based on DNA amplification and sequencing of the fungal internal transcribed spacer (ITS) region was identified as Aspergillus fumigatus . The isolated fungal metabolites4 –12 were unambiguously identified as a series of simple and re-arranged diketopiperazines by analysis of spectroscopic data. t -Butoxycarbonyl group (BOC) derivatization was used to separate the intractable mixture of4 and5 . When all compounds were evaluated for antimicrobial activity against gram positive bacteria, the isolated metabolites showed moderate to weak effects, while the semisynthetic derivatives4a and5a displayed strong activity comparable to the positive control, tetracycline against gram positive bacteria.