Novel dammarane-type triterpenes isolated from hydrolyzate of total Gynostemma pentaphyllum saponins. Issue 16 (15th August 2015)

• Record Type: Journal Article
• Authors: Zhang, Xiao-Shu; Cao, Jia-Qing; Zhao, Chen; Wang, Xu-de; Wu, Xiao-jun; Zhao, Yu-Qing
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 16(2015)
• Page Start: 3095
• Page End: 3099
• Publication Date: 2015-08-15
• Subjects: Novel triterpenes -- Cytotoxicity -- Gynostemma pentaphyllum -- Apoptosis; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.06.022
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: In this study, five novel triterpenes were isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum and identified as gypensapogenin H (1 ), gypensapogenin I (2 ), gypensapogenin L (3 ), gypensapogenin J (4 ) and gypensapogenin K (5 ), three of which (1 –3 ) possess unprecedented ring A. All the isolated compounds were evaluated for cytotoxic activities in five cell lines and all the tested compounds showed significant anti-cancer activities against a series of human cancer cell lines, while having much weaker effect on the growth of normal cell. Among them, compound1 showed strong inhibition toward MCF-7 human breast cancer cells (IC50 values 6.85 μM). Further mechanistic study demonstrated that compound1 significantly induced MCF-7 cell apoptosis. Our results indicated that compound1 may be a promising lead agent for further study.