Heat-killed Bifidobacterium animalis subsp. Lactis CECT 8145 increases lean mass and ameliorates metabolic syndrome in cafeteria-fed obese rats. (November 2017)

• Record Type: Journal Article
• Authors: Caimari, Antoni; del Bas, Josep Maria; Boqué, Noemí; Crescenti, Anna; Puiggròs, Francesc; Chenoll, Empar; Martorell, Patricia; Ramón, Daniel; Genovés, Salvador; Arola, Lluís
• Is Part Of: Journal of functional foods. Volume 38:Part A(2017)
• Page Start: 251
• Page End: 263
• Publication Date: 2017-11
• Subjects: Acc1 acetyl CoA carboxylase 1 -- Agrp agouti-related protein -- ANOVA analysis of variance -- Atgl adipose triacylglycerol lipase -- β-actin actin beta -- Ba8145 Bifidobacterium animalis subsp. lactis strain CECT 8145 -- Cart cocaine and amphetamine-regulated transcript -- Cd36 fatty acid translocase, homologue of CD36 -- Cebpα CCAAT/enhancer binding protein alpha -- Cpt1β carnitine palmitoyltransferase 1 beta -- CVD cardiovascular disease -- EWAT epididymal white adipose tissue -- Fas fatty acid synthase -- Fatp1 fatty acid transporter, member 1 -- Ghsr ghrelin receptor -- Gpat glycerol-3-phosphate acyltransferase -- Had hydroxyacyl-CoA dehydrogenase -- HDL-C high density lipoprotein cholesterol -- HOMA-IR homeostasis model assessment-estimated insulin resistance -- Hprt hypoxanthine guanine phosphoribosyl transferase -- Hsl hormone-sensitive lipase -- IWAT inguinal white adipose tissue -- LDL/VLDL-C low density lipoprotein + very-low density lipoprotein cholesterol -- Lpl lipoprotein lipase -- MetS metabolic syndrome -- MWAT mesenteric white adipose tissue -- NEFAs non-esterified fatty acids -- Npy neuropeptide Y -- ObRb long-form leptin receptor -- Pomc proopiomelanocortin -- Pparg2 peroxisome proliferator-activated receptor gamma 2 -- Ppia peptidylprolyl isomerase A -- RCTs randomized controlled trials -- R-QUICKI revised quantitative insulin sensitivity check index -- RWAT retroperitoneal white adipose tissue -- TC total cholesterol -- TG triacylglycerol; Heat-killed probiotics -- Adiposity -- Lean mass -- Metabolic syndrome -- Insulin sensitivity -- Dyslipidaemia; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.09.029
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Heat-killed Bifidobacterium animalis subsp. lactis (Ba8145) reduces rat adiposity. Ba8145 modulates the expression of lipid-related genes in mesenteric white depot. Ba8145 is able to enhance lean mass accretion and energy expenditure in obese rats. Ba8145 has a significant positive effect on insulin sensitivity in obese rats. Ba8145 is able to partially counteract the dyslipidaemia observed in obese rats. Abstract: To evaluate the ability of the heat-killed probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) to ameliorate Metabolic Syndrome (MetS), four groups of male Wistar rats were fed either standard chow (ST) or the obesogenic cafeteria diet (CAF) and were orally supplemented with either heat-killed Ba8145 (10 10 CFU/day) (ST-Ba8145 and CAF-Ba8145 groups) or vehicle (ST-veh and CAF-veh groups) for 84 days. Both ST-Ba8145 and CAF-Ba8145 rats displayed increased energy expenditure (EE) and a decrease of relative mesenteric white adipose tissue (MWAT%). CAF-BA8145 animals showed decreased cumulative energy intake, increased relative lean mass, higher insulin sensitivity, elevated gene expression of adipose triacylglycerol lipase and fatty acid transporter 1 in MWAT and lower circulating levels of non-esterified free fatty acids, LDL/VLDL cholesterol and triacylglycerols than CAF-veh rats. In conclusion, heat-killed Ba8145 intake ameliorates mesenteric adiposity and dyslipidaemia, increases EE and lean mass and improves insulin sensitivity in rats induced to MetS.