Coacervates of whey proteins to protect and improve the oral delivery of a bioactive molecule. (November 2017)

• Record Type: Journal Article
• Authors: Chapeau, Anne-Laure; Bertrand, Nicolas; Briard-Bion, Valérie; Hamon, Pascaline; Poncelet, Denis; Bouhallab, Saïd
• Is Part Of: Journal of functional foods. Volume 38:Part A(2017)
• Page Start: 197
• Page End: 204
• Publication Date: 2017-11
• Subjects: Vitamin B9 -- Encapsulation -- Protection -- Pharmacokinetic -- Bioavailability -- Formulation; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.09.009
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Heteroprotein coacervates ensure a high encapsulation efficiency of vitamin B9. Heterprotein coacervates protects B9 against physical degradation. Encapsulated vitamin showed improved bioavailability in rat. Abstract: The potentiality of heteroprotein complex coacervates as biocarrier for a bioactive was investigated. Vitamin B9 (B9), also known as folic acid, was encapsulated by complex coacervation of two whey proteins (WP), β-lactoglobulin and lactoferrin. The stability and bioavailability of formed B9-WP coacervates was then characterized. Under degradative conditions in vitro (UV light irradiation, and oxidation by H2 O2 ), WP coacervates protected the vitamin against chemical degradation. B9-WP coacervates also showed considerable physical stability over time when incorporated in real food matrices. Compared to unencapsulated B9, oral administration of B9-WP coacervates to healthy rats enhanced the plasma level of the vitamin. This improved bioavailability can be ascribed to the improvement in the solubility of B9 throughout the gastro-intestinal tract. We thus demonstrate the efficiency of WP coacervates as biocarrier for the protection and delivery of small bioactive molecules.