Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones. Issue 20 (15th October 2015)

• Record Type: Journal Article
• Authors: Wang, Yeming; Yan, Hong; Ma, Chao; Lu, Dan
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 20(2015)
• Page Start: 4461
• Page End: 4463
• Publication Date: 2015-10-15
• Subjects: 8-Azapurine -- Carbocyclic nucleoside -- Hydrazones -- Anticancer; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.09.002
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: IC50 = 11.69 μM (human liver cancer Huh-7 cell line). Abstract: A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through a useful procedure starting from amino alcohol and pyrimido dichloride. All the products were characterized by 1 H NMR, 13 C NMR and HRMS spectral analysis and the stereochemical structure of key intermediate was also confirmed by a single crystal X-ray diffraction crystallographic analysis. Moreover, the anticancer activities were evaluated in vitro against human liver cancer Huh-7 cell line and human breast cancer A549 cell line.