Cancer immunotherapy and immune-related response assessment: The role of radiologists in the new arena of cancer treatment. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Nishino, Mizuki; Tirumani, Sree H.; Ramaiya, Nikhil H.; Hodi, F. Stephen
• Is Part Of: European journal of radiology. Volume 84:Issue 7(2015)
• Page Start: 1259
• Page End: 1268
• Publication Date: 2015-07
• Subjects: Immunotherapy -- Cancer -- Oncologic imaging -- Drug toxicity -- Tumor response assessment; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2015.03.017
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: The successful clinical application of cancer immunotherapy has opened a new arena for the treatment of advanced cancers. Cancer immunotherapy is associated with a variety of important radiographic features in the assessments of tumor response and immune-related adverse events. The state-of-the art knowledge of immunotherapy and the related radiologic manifestations are essential for radiologists. Abstract: The recent advances in the clinical application of anti-cancer immunotherapeutic agents have opened a new arena for the treatment of advanced cancers. Cancer immunotherapy is associated with a variety of important radiographic features in the assessments of tumor response and immune-related adverse events, which calls for radiologists' awareness and in-depth knowledge on the topic. This article will provide the state-of-the art review and perspectives of cancer immunotherapy, including its molecular mechanisms, the strategies for immune-related response assessment on imaging and their pitfalls, and the emerging knowledge of radiologic manifestations of immune-related adverse events. The cutting edge clinical and radiologic investigations are presented to provide future directions.