Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005. Issue 22 (15th November 2015)

• Record Type: Journal Article
• Authors: Kim, Jong Won; Ko, Sung-Kyun; Son, Sangkeun; Shin, Kee-Sun; Ryoo, In-Ja; Hong, Young-Soo; Oh, Hyuncheol; Hwang, Bang Yeon; Hirota, Hiroshi; Takahashi, Shunji; Kim, Bo Yeon; Osada, Hiroyuki; Jang, Jae-Hyuk; Ahn, Jong Seog
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 22(2015)
• Page Start: 5398
• Page End: 5401
• Publication Date: 2015-11-15
• Subjects: Diketopiperazine alkaloid -- Pyrimidoindole -- β-Phenylalanine -- Penicillium sp. -- Marine-derived fungus; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.09.026
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1 ), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of1 was determined by ROESY and advanced Marfey's method.