Role of biomarkers in acute traumatic lung injury. Issue 11 (November 2017)

• Record Type: Journal Article
• Authors: Störmann, Philipp; Lustenberger, Thomas; Relja, Borna; Marzi, Ingo; Wutzler, Sebastian
• Is Part Of: Injury. Volume 48:Issue 11(2017)
• Page Start: 2400
• Page End: 2406
• Publication Date: 2017-11
• Subjects: AIS Abbreviated Injury Scale -- ALI Acute Lung Injury -- Ang-2 Angiopoietin-2 -- ARDS Acute Respiratory Distress Syndrome -- AUC Area under the curve -- BAL-F Broncheoalveolar lavage fluid -- BNP Brain Natriuretic Peptide -- CC16 Club Cell protein 16 -- DAMP Damage Associated Molecular Pattern -- ELISA Enzyme Linked Immunosorbent Assay -- HMGB-1 High Mobility Group Protein 1 -- ICAM-1 Intracellular Adhesion Molecule 1 -- IL Interleukin -- kDa Kilodalton -- LTB-4 Leukotriene B4 -- NFκB Nuclear Factor Kappa B -- PAI-1 Plasminogen Activator Inhibitor 1 -- PC Pulmonary Contusion -- PCP III Procollagen Peptipe III -- PMNL Polymorphonuclear Leukocyte -- RAGE Receptor for Advanced Glycation End Products -- SP-A/B/C/D Surfactant Protein A/B/C/D -- TLR Toll Like Receptor -- TNFα Tumor Necrosis Factor α -- VEGF Vasoendothelial Growth Factor -- VWF Von Willebrand Factor; Acute lung injury -- Adult respiratory distress syndrome -- Thoracic trauma -- Biomarker; Wounds and injuries -- Surgery -- Periodicals; Accidents -- Periodicals; Wounds and Injuries -- surgery -- Periodicals; Lésions et blessures -- Chirurgie -- Périodiques; Electronic journals; Electronic journals; 617.1
• DOI: 10.1016/j.injury.2017.08.041
• Languages: English
• ISSNs: 0020-1383

Abstract

Abstract: In severely injured patients severe thoracic trauma is common and can significantly influence the outcome of these critically ill patients by increased rates of mainly pulmonary complications. Furthermore, patients who sustained thoracic trauma are at increased risk for Acute Lung Injury (ALI) or Adult Respiratory Distress Syndrome (ARDS). Therapeutic options are limited, basically consisting of prophylactic antibiotic therapy and changing patient's positions. It is known, that ALI and ARDS differ clinically and pathobiologically from ALI/ARDS caused by other reasons, but the exact pathology remains elusive. Due to that no reliable predictive or surveillance biomarkers could be established for clinical diagnosis and identification of patients at high risk for acute traumatic lung injury. Nevertheless, there are plenty of promising markers that need to be further elucidated in larger case numbers and multicenter studies. This article sums up the recent status of those promising clinical biomarkers.