The role of oxidative DNA damage in radiation induced bystander effect. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Havaki, Sophia; Kotsinas, Athanassios; Chronopoulos, Efstathios; Kletsas, Dimitris; Georgakilas, Alexandros; Gorgoulis, Vassilis G.
• Is Part Of: Cancer letters. Volume 356:Issue 1(2015)
• Page Start: 43
• Page End: 51
• Publication Date: 2015-01-01
• Subjects: AP-1 activation protein-1 -- ARF alternative reading frame -- ATM ataxia-telangiectasia mutated -- ATR ataxia-telangiectasia mutated Rad3-related -- BER base excision repair -- Cdc6 cell division cycle 6 -- cfDNA circulating oxidized DNA -- COX-2 cyclooxygenase -2 -- DDR DNA damage response -- DSB double-strand break -- ecDNA extracellular DNA -- ERK extracellular signal-related kinase -- GJIC gap junction intercellular communication -- HR homologous recombination -- iNOS inducible nitric oxide synthase -- IR ionizing radiation -- JAK2 Janus-kinase 2 -- JNK c-Jun N-terminal kinase -- MAPK mitogen-activated protein kinase -- MN micronuclei -- mtDNA mitochondrial DNA -- NER nucleotide excision repair -- NHEJ non-homologous end-joining -- NO nitric oxide -- OCDL oxidative clustered DNA lesion -- RNS reactive nitrogen species -- ROS reactive oxygen species -- RPA replication protein A -- SCE sister chromatid exchanges -- SIPS stress-induced premature senescence -- SSB single strand DNA breaks -- STAT3 signal transducer and activator of transcription 3 -- TNF-α tumor necrosis factor-α -- γ-H2AX phosphorylated histone H2AX; Radiation induced bystander effect -- Oxidative stress -- Oxidative DNA damage -- DDR response -- Cancer; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.01.023
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Ionizing radiation (IR) has been described as a double-edged sword, since it is used for diagnostic and therapeutic medical applications, and at the same time it is a well known human mutagen and carcinogen, causing wide-ranging chromosomal aberrations. It is nowadays accepted that the detrimental effects of IR are not restricted only in the irradiated cells, but also to non-irradiated bystander or even distant cells manifesting various biological effects. This review presents the role of oxidative stress in the induction of bystander effects referring to the types of the implicated oxidative DNA lesions, the contributing intercellular and intracellular stress mediators, the way they are transmitted from irradiated to bystander cells and finally, the complex role of the bystander effect in the therapeutic efficacy of radiation treatment of cancer.