Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology. Issue 1 (1st January 2015)

• Record Type: Journal Article
• Authors: Hatzi, Vasiliki I.; Laskaratou, Danae A.; Mavragani, Ifigeneia V.; Nikitaki, Zacharenia; Mangelis, Anastasios; Panayiotidis, Mihalis I.; Pantelias, Gabriel E.; Terzoudi, Georgia I.; Georgakilas, Alexandros G.
• Is Part Of: Cancer letters. Volume 356:Issue 1(2015)
• Page Start: 34
• Page End: 42
• Publication Date: 2015-01-01
• Subjects: DSBs double strand breaks -- CNS central nervous system -- COX-2 cyclooxygenase-2 -- CFE colony forming efficiency -- GJIC gap-junction mediated intercellular communication -- HCC hepatocellular carcinoma -- HR homologous recombination -- IL-1 interleukin-1 -- IR ionizing radiation -- LET linear energy transfer -- PCC premature chromosome condensation -- RIBE radiation induced bystander effects -- ROS reactive oxygen species -- SCEs sister chromatid exchanges -- TNF tumor necrosis factor; Bystander effects -- Non-targeted effects -- Ionizing radiation -- In vivo -- Radiobiology -- Carcinogenesis; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2013.11.018
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.