Graphene: A versatile platform for nanotheranostics and tissue engineering. (January 2018)

• Record Type: Journal Article
• Authors: Geetha Bai, Renu; Ninan, Neethu; Muthoosamy, Kasturi; Manickam, Sivakumar
• Is Part Of: Progress in materials science. Volume 91(2018)
• Page Start: 24
• Page End: 69
• Publication Date: 2018-01
• Subjects: Graphene -- Nanotheranostics -- Tissue engineering -- Nanomedicine -- Cancer -- Imaging -- Personalized -- Regenerative medicine; 2D 2 dimensional -- 3D 3 dimensional -- AFP alpha-fetoprotein -- Ag silver -- AGO amine functionalized GO -- ALP alkaline phosphatase -- Apt aptamer -- SsDNA single-strand DNA -- AS1411 anti-nucleolin aptamer -- AuNR gold nanorod -- BA boronic acid -- BMP 2-bone morphogenetic protein -- BPEI polyethylenimine -- CD cardiovascular diseases -- Ce6 chlorine e 6 -- CEA carcinoembryonic antigen -- CGdots carboxylated GQDs -- CNT carbon nanotubes -- CPSS construct porous silica shell -- CTE cardiac tissue engineering -- Cu copper -- Cur curcumin -- CV cyclic voltammetry -- CVD chemical vapour deposition -- DEN dendrimers capped with amino groups -- DOX doxorubicin -- DTPA diethylenetriaminepentaacetic acid -- DVDMS sinoporphyrin sodium -- DVDMS sinoporphyrin sodium -- E. coli Escherichia coli -- ECM extracellular matrix -- EDC N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride -- EGFR anti-epidermal growth factor receptor -- ESCs embryonic stem cells -- FAM-PdT30 carboxyfluorescein conjugated model drug poly dT30 -- Fe3O4 ion oxide -- FG fluorinated graphene -- FLG few-layer graphene -- Gd gadolinium -- GFP green fluorescence protein -- GGMPN miR-122-loaded gold nanoparticles on graphene nanocomposites -- GM gelatin methacrylate -- GN graphene nanosheets -- GNC nanoclusters -- GNS graphene nanosheets -- GO graphene oxide -- Au Gold -- GQD graphene quantum dots -- GOF folate conjugated GO -- GSPs gold super particles -- H2O2 hydrogen peroxide -- HA hyaluronic acid -- HA* hypocrellin A -- HCV hepatitis virus C -- hESCs human embryonic stem cells -- HL-60 human promyelocytic leukemia -- hMSC human mesenchymal stem cells -- hNSCs human neural stem cells -- HPA hydroxyapatite -- HPPH 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha -- ICG-PD indocyanine green-loaded polydopamine -- IONP iron oxide nanoparticles -- iPSCs induced pluripotent stem cells -- LOGr low oxygen graphene -- MB molecular beacon -- MGMSPID magnetic graphene-based mesoporous silica -- MPC 2-(methacryloyloxy) ethyl phosphorylcholine -- MRI magnetic resonance imaging -- MSCs mesenchymal stem cells -- MSN mesoporous silica nanoparticles -- MSP mesoporous silica -- MTT 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide -- MWCNT multi-walled CNT -- NGO nano GO -- NIR near-infrared -- NLS nuclear localized signals -- NS gold nanostar -- NSCs neural stem cells -- OH hydroxyl -- PAA polyallylamine -- PAH poly-allylamine hydrochloride -- PANI polyaniline -- Pc phthalocyanine -- PCL polycaprolactone -- PDT photodynamic therapy -- PEG polyethylene glycol -- PEI polyethylenimine -- Pep peptide -- PET positron emission tomography -- PF127 pluronic F127 -- PIG polymer stabilized iron oxide-graphene -- PLGA poly (lactic-co-glycolic acid) -- PLL poly (L-lysine) -- PPF polypropylene fumarate -- PPGA PEG modified PEI-graphene-Au composite -- PPIG4 polypropylenimine generation 4 -- Pt platinum -- PTT photothermal therapy -- PU polyurethane -- PVA polyvinyl alcohol -- QD quantum dot -- R6G rhodamine 6G -- RATRP reverse atom transfer radical polymerization -- RB Rose Bengal -- RGO reduced graphene oxide -- RGONs reduced GO nanoparticles -- RLN regional lymph node -- ROS reactive oxygen species -- SBF simulated body fluid -- SDT sonodynamic therapy -- SF sorafenib -- siRNA small interfering RNA -- SPR surface plasmon resonance -- TiO2 titania -- VEGF vascular endothelial growth factor -- ZnS:Mn manganese doped zinc sulfide; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2017.08.004
• Languages: English
• ISSNs: 0079-6425

Abstract

Graphical abstract: Abstract: The sustained extensive research on graphene and its derivatives in the last decade portrayed its significance in the field of material science and carved its own niche in nanotechnology. Starting from the simple pencil, the role of graphene now extends to a lifesaver through innovations in nanomedicine specifically the early detection of abnormalities and efficient treatments. Graphene has the potential to satisfy the nanotechnological concepts of personalized and regenerative medicine for a disease-free future. The functionalization techniques ameliorate graphene for improved solubility, stability, loading capacity, etc. which makes it an ideal nanosystem for theranostic applications such as biosensing, drug delivery, gene therapy, bioimaging, phototherapy and hybrid theranostics. In addition, due to its electrically tunable surface chemistry, maximal surface-to-volume ratio, easy functionalization capacity and mechanical robustness, graphene gained enormous attention in tissue engineering specifically in cardiac, nerve, bone, skin and stem cells. This review focusses on the recent developments in graphene-based nanotheranostics and tissue engineering, which reveals the hidden potential of modern medical notions in efficiently handling the variety of abnormalities. Moreover, it raises the necessity of successful therapeutic systems to transfer from bench-to-bedside through clinical trials to enhance the current treatment scenario.