Benzophenone and its analogs bind to human glyoxalase 1. Issue 22 (15th November 2015)

• Record Type: Journal Article
• Authors: Mihai, Doina M.; Hall, Steven; Deng, Haiteng; Welch, Christopher J.; Kawamura, Akira
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 22(2015)
• Page Start: 5349
• Page End: 5351
• Publication Date: 2015-11-15
• Subjects: GLO1 -- Photoaffinity-labeling -- Off-target -- Ketoprofen -- Fenofibrate -- Doxorubicin; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.09.036
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed.