Disseminated BCG in an infant with interleukin-12 receptor B1 (IL12RB1) deficiency. (February 2015)

• Record Type: Journal Article
• Authors: Senanayake, Manouri P.; Kumararatne, D. S.; Doffinger, Rainer; Barcenas-Morales, Gabriela
• Is Part Of: Paediatrics and international child health. Volume 35:Number 1(2015:Feb.)
• Page Start: 69
• Page End: 71
• Publication Date: 2015-02
• Subjects: Neonatal BCG vaccination, -- Mendelian susceptibility to mycobacterial disease, -- Interleukin-12 receptor B1 (IL12RB1) deficiency; Pediatrics -- Developing countries -- Periodicals; Children -- Health and hygiene -- Developing countries -- Periodicals; Children -- Diseases -- Developing countries -- Periodicals; 618.920009172405
• DOI: 10.1179/2046905514Y.0000000129
• Languages: English
• ISSNs: 2046-9047

Abstract

Abstract : Although neonatal vaccination with bacille Calmette–Guérin (BCG) is considered to be safe, complications with disseminated disease are associated with underlying immuno-deficiency disorders. A BCG-vaccinated 4-month-old girl of Sri Lankan parentage developed progressive left axillary lymphadenopathy and severe bronchopneumonia. Lymph node biopsy demonstrated epithelioid granulomata and acid-fast bacilli. An older sibling had had a similar clinical presentation and the outcome had been fatal. Investigation for immuno-deficiency detected complete IL12RB1 deficiency. Full recovery followed a prolonged course of anti-tuberculous chemotherapy. She was put on lifelong isoniazid prophylaxis. In HIV-negative infants with unusual complications related to BCG vaccination, a primary immuno-deficiency disorder should be considered.