Effects of pentoxifylline on gentamicin-induced nephrotoxicity. (23rd August 2013)

• Record Type: Journal Article
• Authors: Kasap, Belde; Türkmen, Mehmet; Kiray, Müge; Kuralay, Filiz; Soylu, Alper; Tuğyan, Kazım; Kavukçu, Salih
• Is Part Of: Renal failure. Volume 35:Number 10(2013)
• Page Start: 1376
• Page End: 1381
• Publication Date: 2013-08-23
• Subjects: Apoptosis -- gentamicin -- nephrotoxicity -- oxidative stress -- pentoxifylline; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2013.828359
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: We aimed to investigate the underlying mechanisms responsible for the renoprotective effects of pentoxifylline (PTX) in gentamicin (GEN)-induced nephropathy. On this purpose, 26 female Wistar rats (200–250 g) were included and four groups were formed. The first one was the control group ( n :5). The rats in other groups ( n :7 for each) received 50 mg/kg twice daily intraperitoneal (i.p.) PTX, 100 mg/kg i.p. GEN and both GEN and PTX at the same doses for consecutive 8 days, respectively. Rats were weighed both at the beginning and end of the study. After the last dose, 24-hour urines were collected and the rats were sacrificed. Blood samples and kidney tissues were obtained for biochemical, histological, oxidative stress, and apoptotic parameters. Body weights were similar in all groups at the beginning of the study. Rats in GEN group had significant weight loss, tubular damage, and increased apoptosis, while GEN + PTX group had significantly better outcomes. Scr, urinary protein/creatinine, and TBARS levels were significantly higher and Ccr and SOD levels were significantly lower in GEN and GEN + PTX groups in comparison to control and PTX groups, but the levels were similar between GEN and GEN + PTX groups. In conclusion, concomitant administration of PTX provides renoprotection via suppressing apoptosis in GEN-induced nephropathy.