External Beam Radiotherapy ± Chemotherapy in the Treatment of Anal Canal Cancer: A Single-Institute Long-Term Experience on 100 Patients. (3rd July 2014)

• Record Type: Journal Article
• Authors: De Bari, Berardino; Buglione, Michela; Maddalo, Marta; Lestrade, Laëtitia; Spiazzi, Luigi; Vitali, Paola; Barbera, Fernando; Magrini, Stefano M.
• Is Part Of: Cancer investigation. Volume 32:Number 6(2014)
• Page Start: 248
• Page End: 255
• Publication Date: 2014-07-03
• Subjects: Anal cancer -- Radiotherapy -- Chemotherapy -- Toxicity -- Local control -- Radiochemotherapy; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2014.907420
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract : One-hundred patients treated with curative radiotherapy (RT) ± chemotherapy (CT) for an anal canal carcinoma (T1–4N0–3M0) were retrospectively analyzed. Five- and 10-year local control (LC) rates were 73% and 67%, respectively. Acute and late G3–G4 toxicity rates were 32% and 12%, respectively. Two patients underwent a colostomy for a G4 anal toxicity. This study confirms the outcomes of RT ± CT in the treatment of anal canal cancer. Concomitant CT and LC statistically influenced Overall Survival and Colostomy-Free Survival. CT also statistically reduced the risk of nodal relapse. High rates of acute skin toxicity impose tailored volumes and techniques of irradiation.