Eight new cycloartane triterpenoids from Beesia calthifolia with hepatoprotective effects against d-galactosamine induced L02 cell damage. Issue 18 (15th September 2015)

• Record Type: Journal Article
• Authors: Gan, Li-She; Zheng, Dan-Jun; Liu, Qian; Zhou, Jing; Zhang, Min-Zhe; Yao, Wei; Shao, Bai-Hao; Mo, Jian-Xia; Zhou, Chang-Xin
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 18(2015)
• Page Start: 3845
• Page End: 3849
• Publication Date: 2015-09-15
• Subjects: Beesia calthifolia -- Cycloartane triterpenoids -- Hepatoprotective activity -- Configuration -- Structure elucidation; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.07.070
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Fourteen 20, 24-epoxy-cycloartane triterpenoids, including eight new ones (1 –8 ), were isolated from 95% ethanol extract of the rhizomes of Beesia calthifolia . Their structures were determined by spectroscopic and chemical methods, especially 2D NMR and HRMS techniques. Among them, four new compounds (1 –4 ) possess carbonyl groups at C-16, which were rarely found in cycloartane triterpenoids from this genus. Relative configuration at C-12 in beesioside III (9 ) and its aglycone (10 ) was revised to be 12α-OH rather than the reported 12β-OH. Some of the compounds showed potential hepatoprotective activities against human hepatic L02 cell damage induced byd -galactosamine.