Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp. Issue 10 (15th May 2015)

• Record Type: Journal Article
• Authors: Kim, Eun La; Wang, Haibo; Park, Ju Hee; Hong, Jongki; Choi, Jae Sue; Im, Dong Soon; Chung, Hae Young; Jung, Jee H.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 10(2015)
• Page Start: 2096
• Page End: 2099
• Publication Date: 2015-05-15
• Subjects: Cytochalasin -- Jellyfish-derived fungus -- Phoma sp. -- Nemopilema nomurai -- Cytotoxicity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.03.080
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Four new cytochalasin derivatives (1 –4 ), together with proxiphomin (5 ), were isolated from a jellyfish-derived fungus Phoma sp. The planar structures and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed moderate cytotoxicity against a small panel of human solid tumor cell lines (A549, KB, and HCT116).